Inflammatory Compounds
Essential Fats are required
for the production of prostagladins, which contributes to either
inflammation or anti-inflammation.
To understand the role of the essential fats lets look at
3 compounds first.
Prostaglandins
Prostaglandins are manufactured in every cell and they have
different roles and they are made from essential fatty acids.
They can either have an inflammatory (ie contribute to
allergies) or anti-inflammatory effect (ie reduces the problems of allergies).
The prostaglandins produced in excess that lead to inflammation
are called PGE2, and that which subdue inflammation and allergic reaction are
called PGE1 & PGE3.
PGE1 & PGE3 thus protect the body against the deterioration
effects of PGE2 prostagladins such as high blood pressure, sticky platelets,
inflammation and lowered immune function.
Arachadonic acid & Leukotrienes
Arachadonic acid (AA) promotes wound healing and blood platelet
stickiness and is needed in nerve, brain and eye health.
Only a small quantity is required and excess are converted to
leukotrienes which promotes inflammation.
AA is found in saturated fats and they are converted to PGE2 and
the synthesis of IgE immune cells involved in atopic allergy.
Omega-3 fats work against the conversion to PGE2 by replacing
the AA in cell membranes. It takes a few months to see the effect of
increase intake of omega-3 in your diet.
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Role of Essential Fats
Linoleic Acid (LA) and Gamma-linolenic-acid (GLA)
LA, a member of the omega-6 fats, is converted by an enzyme
called D6D (delta-6-desaturase) into a fatty acid called GLA.
(NB: GLA can also be obtained from evening prim rose oil,
starflower oil etc or from supplements)
GLA is then converted to DGLA (dihomogamma-linolenic acid),
which can:
-
be converted to PGE1, which inhibits inflammation and
enhances white blood cells performance in the immune system or
-
be converted to arachadonic acid, which eventually are
converted to leukotrienes and PGE2 and thromboxanes. These causes
inflammation and block clot formation.
PGE3 & omega-3
The other essential fatty acid is ALA (alpha-linolenic acid)
which is a member of the omega-3 fats.
The ALA is then converted to EPA (eicosapentanoic acid) and DHA
(Decosahexanoic acid). The highest concentration of these 2
poly-unsaturated fats are found in oily fish.
From the EPA & DHA, PGE3 are produced. These are
critical hormones regulating cellular activity. PGE3 has
anti-clotting properties and reduces inflammation
Omega-3 replaces the AA in the cell membrane. Numerous
studies have shown that omega-3 fatty acids help lower cholesterol and blood
triglycerides
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Fish and Plant oil supplement
In the past, the most common form of supplementation was cod
liver oil.
Today, it is more adviceable to take fish oil because the liver
oil could be contaminated and the liver is the most toxic organ. Superior
cod liver oil would be the best bet if you prefer cod liver oil.
For vegetarian, flaxseed oil is a good source of omega-3.
Point to note is the balance between omega-3 and omega-6. For
optimal health, you need a ratio of omega–6 to omega–3 fatty acids somewhere
between 1:1 and 4:1. The typical modern diet now usually provides a ratio
of too much omega-6, as high as 30 times the amount we need.
If you have a deficiency in omega-3 fat, but not omega-6 (which
is easily consumed through eating vegetables) it can make the condition worse if
supplementing with GLA omega-6 such as evening prime rose.